Jian Ding Selected Research

Tyrosine Kinase Inhibitors

1/2023	Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo.
1/2018	PBA2 exhibits potent anti-tumor activity via suppression of VEGFR2 mediated-cell proliferation and angiogenesis.
1/2008	The marine-derived oligosaccharide sulfate (MdOS), a novel multiple tyrosine kinase inhibitor, combats tumor angiogenesis both in vitro and in vivo.
10/2005	In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects.
6/2005	11,11'-dideoxy-verticillin: a natural compound possessing growth factor receptor tyrosine kinase-inhibitory effect with anti-tumor activity.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Jian Ding Research Topics

Disease

242	Neoplasms (Cancer) 06/2024 - 12/2002
46	Breast Neoplasms (Breast Cancer) 02/2024 - 07/2004
38	Neoplasm Metastasis (Metastasis) 06/2024 - 07/2004
20	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 09/2006
19	Leukemia 01/2022 - 12/2002
16	Carcinoma (Carcinomatosis) 08/2016 - 07/2003
12	Carcinogenesis 06/2024 - 08/2005
12	Necrosis 03/2024 - 09/2009
12	Infections 01/2022 - 03/2002
11	Stomach Neoplasms (Stomach Cancer) 05/2023 - 01/2008
11	Hepatocellular Carcinoma (Hepatoma) 01/2021 - 07/2004
10	Lung Neoplasms (Lung Cancer) 12/2023 - 06/2005
10	Parkinson Disease (Parkinson's Disease) 05/2022 - 08/2015
9	Ovarian Neoplasms (Ovarian Cancer) 12/2023 - 08/2004
9	Inflammation (Inflammations) 01/2023 - 11/2011
9	Colonic Neoplasms (Colon Cancer) 04/2021 - 04/2005
9	Hypoxia (Hypoxemia) 01/2020 - 12/2004
8	Ischemia 03/2024 - 05/2015
8	Body Weight (Weight, Body) 01/2023 - 10/2011
7	Fibrosis (Cirrhosis) 01/2024 - 11/2009
7	Brain Ischemia (Cerebral Ischemia) 05/2023 - 02/2014
7	Non-alcoholic Fatty Liver Disease 03/2023 - 01/2019
7	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 04/2005
6	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 10/2023 - 12/2019
6	Edema (Dropsy) 01/2021 - 01/2018
6	HIV Infections (HIV Infection) 01/2018 - 03/2010
5	Esophageal Squamous Cell Carcinoma 12/2023 - 10/2019
5	Adenocarcinoma 11/2023 - 06/2005
5	Wounds and Injuries (Trauma) 01/2021 - 02/2008
5	Acquired Immunodeficiency Syndrome (AIDS) 01/2018 - 08/2004
5	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2012 - 02/2007
4	Bites and Stings (Sting) 03/2024 - 12/2022
4	Ischemic Stroke 11/2023 - 03/2020
4	Squamous Cell Carcinoma of Head and Neck 09/2023 - 01/2021
4	B-Cell Lymphoma (Lymphoma, B Cell) 01/2022 - 12/2018
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 11/2017
4	Hypersensitivity (Allergy) 01/2020 - 05/2005
4	Adenocarcinoma of Lung 01/2018 - 07/2004

Drug/Important Bio-Agent (IBA)

40	Proteins (Proteins, Gene)FDA Link 06/2024 - 12/2004
33	Phosphotransferases (Kinase)IBA 01/2022 - 10/2005
24	Biomarkers (Surrogate Marker)IBA 03/2023 - 10/2005
15	DNA (Deoxyribonucleic Acid)IBA 01/2024 - 10/2005
13	Tyrosine (L-Tyrosine)FDA Link 04/2024 - 04/2005
13	salvicineIBA 09/2008 - 12/2002
11	CytokinesIBA 04/2024 - 01/2005
10	ErbB Receptors (EGF Receptor)IBA 01/2023 - 12/2008
10	MicroRNAs (MicroRNA)IBA 10/2022 - 01/2013
10	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 12/2004
9	Long Noncoding RNAIBA 06/2024 - 01/2014
9	EnzymesIBA 03/2024 - 08/2015
9	Messenger RNA (mRNA)IBA 01/2024 - 10/2004
9	heparanaseIBA 08/2018 - 10/2005
8	Therapeutic UsesIBA 01/2023 - 12/2005
7	RNA (Ribonucleic Acid)IBA 06/2024 - 09/2014
7	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 11/2023 - 01/2017
7	IronIBA 10/2023 - 07/2008
7	Small Interfering RNA (siRNA)IBA 02/2020 - 04/2007
7	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 02/2017 - 01/2003
7	trioctyl phosphine oxide (TOPO)IBA 12/2014 - 02/2007
6	Gefitinib (Iressa)FDA Link 01/2022 - 11/2015
6	Type II DNA Topoisomerases (Topoisomerase II)IBA 04/2015 - 08/2003
5	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2024 - 07/2008
5	CYH33IBA 12/2023 - 10/2018
5	Transcription Factors (Transcription Factor)IBA 10/2023 - 10/2010
5	osimertinibIBA 01/2023 - 01/2019
5	Tyrosine Kinase InhibitorsIBA 01/2023 - 06/2005
5	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 07/2003
5	Antineoplastic Agents (Antineoplastics)IBA 03/2018 - 10/2004
5	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 07/2004
5	Epidermal Growth Factor (EGF)IBA 12/2017 - 08/2004
5	TubulinIBA 07/2014 - 04/2006
5	OligosaccharidesIBA 06/2014 - 02/2005
5	oligomannurarate sulfateIBA 06/2014 - 09/2006
5	TOR Serine-Threonine KinasesIBA 01/2014 - 01/2009
5	Fibronectins (Fibronectin)IBA 11/2009 - 05/2005
5	Focal Adhesion Protein-Tyrosine KinasesIBA 11/2008 - 04/2005
4	InflammasomesIBA 03/2024 - 06/2017
4	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 12/2023 - 11/2014
4	Fluorouracil (Carac)FDA LinkGeneric 09/2023 - 06/2005
4	Interleukin-6 (Interleukin 6)IBA 02/2023 - 01/2019
4	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2023 - 01/2017
4	AntigensIBA 01/2023 - 02/2005
4	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 10/2015
4	Amino Acids FDA Link 01/2023 - 10/2019
4	Histones (Histone)IBA 01/2023 - 01/2013
4	AntioxidantsIBA 04/2022 - 08/2015
4	LipidsIBA 01/2022 - 10/2015
4	PlasticsIBA 01/2021 - 01/2017
4	Angiogenesis InhibitorsIBA 01/2021 - 04/2006
4	Hematoxylin (Haematoxylon)IBA 01/2021 - 07/2011
4	Sirolimus (Rapamycin)FDA Link 02/2020 - 09/2010
4	Adenosine Triphosphate (ATP)IBA 01/2019 - 11/2006
4	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 11/2004

Therapy/Procedure

102	Therapeutics 06/2024 - 08/2003
16	Drug Therapy (Chemotherapy) 01/2024 - 01/2006
11	Oral Administration 02/2022 - 01/2014
10	Immunotherapy 06/2024 - 01/2018
9	Electroacupuncture 05/2023 - 02/2014
5	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2024 - 05/2007
4	Perforator Flap 03/2024 - 05/2017